|
Research InterestsDr Ross Grant | | (Position Details) | | Phone 02 9385 3742 | | Email | | | | School/Unit |
| School of Medical Sciences | |
| | Broad Research Areas | |
|
Neuroscience
Pharmacology
Inflammation
| |
| | | | Specific Research Keywords | |
| Neuropharmacology
Neurodegeneration
Central nervous system disease injury and repair
Cell Metabolism
Neuropharmacology
| |
| | | | Research Interests | |
| 1) Investigation of the role of oxidative stress and NAD metabolism on brain cell death and cellular degeneration.
| |
| | | | Project Topics for current Honours Students |
| Modification of oxidative stress and NAD metabolism in vivo: implications for cell degenerative disorders and aging | |
| | | | Teaching Interests | |
| Pharmacolgy; Ranging from antidepressants to therapeutic intervention in neurodegenerative disease to the fundamentals of Pharmacokinetics for Science and Medical students. | |
| | | | Society Memberships & Professional Activities | |
| Australian Society for Medical Research (ASMR)
Australian Neuroscience society (ANS)
Australian Society of Clinical & Experimental Pharmacology and Toxicology
Nutrition Society of Australia (NSA) | |
| | | | Funding Sources | |
| Novus Foundation
Australasian Research Institute | |
| | | | Other Postgraduate Research | |
|
-Adolescent health - impact of nutrition and lifestyle behaviours on cardiovascular and neuro-psychological health | |
| | | | Key works/Publications | |
| o Braidy N , Grant R, Adams S, Guillemin G. Neuroprotective Effects of Naturally Occurring Polyphenols on Quinolinic Acid-Induced Excitotoxicity in Human Neurons. FEBS J. (in press, Nov 2009)
o Yiquan Chen, Roger Stankovic, Karen Cullen, Vincent Meininger, Brett Garner, Sarah Coggan*, Ross Grant, Bruce J. Brew, and Gilles J. Guillemin The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis. J. Neurotox Res (in press Oct 2009
o Brady N, Grant R, Guillemin G. Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons. J. Neurotox Res 16(1):77-86 2009
o Grant RS, Coggan S, Smythe GA. The Physiological action of Picolinic Acid in the Human Brain. (invited Review). Int. J. Tryp. Res. 2:71-79 2009
o Braidy N Grant R, Brew BJ, Adams S, Jayasena T, Guillemin G. Effects of Kynurenine Pathway Metabolites on Intracellular NAD+ synthesis and Cell Death in Human Primary Astrocytes and Neurons. Int J. Tryp. Res. (in press) 2009
o Coggan S, Smythe G, Bilgin A, Grant R. Age and Circadian Influences on Picolinic acid concentrations in human Cerebrospinal Fluid. J. Neurochem. 108:1220-1225 2009
o Grant R, Bilgin A, Zeuschner C, Guy T, Pearce R, Hokin B, Ashton J. The Relative Impact of a Vegetable-Rich Diet On Key Markers Of Health In A Cohort Of Australian Adolescents. Asia Pac J Clin Nutr 2008;17 (1):107-115
o Braidy N, Guillemin G, Grant R. Promotion of Cellular NAD+ Anabolism: Therapeutic Potential for Oxidative Stress in Ageing and Alzheimer’s Disease. (Review) Neurotox. Res. 2008; 13 (4):1-12
o Jayasena T, Grant R, Keerthisinghe N, Solaja I and Smythe G. Membrane permeability of redox active metal chelators: An important element in reducing hydroxyl radical induced NAD+ depletion in neuronal cells Neurosci. Res. 57(3):454-61 2007
o Poljak A, Grant R, Austin CJ, Jamie JF, Willows RD, Takikawa O, Littlejohn TK, Truscott RJ, Walker MJ, Sachdev P, Smythe GA. Inhibition of indoleamine 2,3 dioxygenase activity by H(2)O(2). Arch Biochem Biophys. 450(1):9-19 2006
o Grant R S, Kapoor V. Inhibition of indoleamine 2,3-dioxygenase activity in IFN- stimulated astroglioma cells decreases intracellular NAD levels. Biochem. Pharmacol. 66: 1033-1036 2003
o Smythe GA, Poljak A, Bustamante S, Braga O, Maxwell A, Grant R, Sachdev P. ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue. Adv Exp Med Biol. 2003;527:705-12.
o Smythe G, Braga O, Brew B, Grant R S, Guillemin G J, Kerr S J, Walker D W. Concurrent quantification of quinoloinic, picolinic and nicotinic acids using electron capture negative-ion gas chromatography-mass spectrometry. Anal Biochem 301: 21-26, 2002
o Grant R S, Naif H, Thuruthil S, Nasr N, Littlejohn T, Takikawa O, Kapoor V. Induction of indoleamine 2,3-dioxygenase in primary human macrophages by human immunodeficiency virus type 1 is strain dependent. J Virol 74(9):4110-4115 2000
o Grant R S, Naif H, Espinosa M, Kapoor V. IDO induction in IFN-gamma activated astroglial: a role in improving cell viability during oxidative stress. Redox Rep 5(2-3):101-104, 2000
o Grant R S, Naif H, Thuruthil S J, Nasr N, Littlejohn T, Takikawa O, Kapoor V. Induction of indoleamine 2,3-dioxygenase in primary human macrophages by HIV-1. Redox Rep 5 (2-3):105-107, 2000
o Grant R S, Passey R, Matanovic G, Smythe G, Kapoor V. Evidence for increased de novo synthesis of NAD in immune-activated RAW264.7 macrophages: a self protective mechanism? Arch Biochem Biophys 372(1):1-7, 1999
o Grant R S, Kapoor V. Murine glial cells regenerate NAD, after peroxide-induced depletion, using either nicotinic acid, nicotinamide or quinolinic acid as substrates. J Neurochem 70: 1759-1763, 1998 | |
| | |
Profile last updated: 10/11/2009 Need to update your profile? Login to your profile with your Staff ID, prefixed by a lower case "s" or "z" (eg s1234567 or z1234567), and UniPass to update your profile. If you have any problems please send an email to .
|
|