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| Dr Anthony Don
UNSW Cancer Research CentreStatement of Interests:
Sphingosine 1-phosphate (S1P) is a potent and essential signaling metabolite that promotes cell proliferation, migration, and survival, amongst other higher physiological roles. We use biochemistry and molecular biology techniques to investigate the molecular basis for cell proliferation and survival mediated by S1P, and to study the known contribution that this molecule makes to the dysregulated survival of cancer cells. We are also investigating how the immediate biosynthetic precursors to S1P, ceramide and sphingosine, promote cell death (in direct contrast to S1P). In this regard we are interested in the design and synthesis of sphingosine analogues as a new class of anti-cancer agents. Our hypothesis is that when these molecules reach a threshhold intracellular concentration, they flick a molecular "switch", causing a change in the cell state from proliferation/survival to apoptosis.
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| Dr David Ziegler
School of Women's and Children's HealthStatement of Interests:
David Ziegler's research interest is in the translation of novel targeted therapeutics from the laboratory to the bedside. He received a Fulbright Scholarship to attend the Dana Farber Cancer Institute, where he discovered novel combination therapies that target the apoptotic pathway in malignant gliomas. He is currently pursuing these research findings in collaboration with Prof Michelle Haber at the Children's Cancer Institute, Australia. He has established an early phase clinical trials unit at Sydney Children's Hospital to facilitate the translation of laboratory findings to the clinic.
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| Dr Margaret Faedo
Prince of Wales Clinical SchoolStatement of Interests:
One of the biggest challenges facing health care systems today is providing patients with access to new and emerging drug treatments, and at the same time ensuring the sustainability of funding. Local health care delivery systems, such as area health services, hospitals and private health insurers are under considerable pressure to fund medicines rejected, restricted or pending approval by the Pharmaceutical Benefits Advisory Committee. There is a need to develop freely available economic models that can adapt easily to local circumstances. This requires new policies and health care practices developed on the basis of sound clinical and economic evidence. Our NHMRC funded program aims to build and disseminate readily accessible evidence about the cost effectiveness of cancer medicines in clinical practice. These models will be available on the Cancer Institute NSW Standard Treatment (CI-SCaT) program, an online resource of more than 500 peer-reviewed cancer treatment guidelines. This is a world first program which will have implications beyond cancer management, addressing one of the most enduring problems in health care: the translation of economic evidence into policy and clinical practice.
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