Molecular Machines Group

Group Leader: Dr Till Böcking

Overview of Research

We aim to elucidate the mechanisms of molecular machines in cellular assembly and disassembly processes. One of our research interests is focused on understanding how ATP-driven molecular chaperones mediate the disassembly of macromolecular complexes (Nat Struct Mol Biol 2011) and the restructuring of protein oligomers and aggregates in neurodegenerative diseases. Another project is aimed at elucidating the assembly pathways of specialised actin filaments decorated with actin-binding proteins.

To understand these processes we use a combination of biochemical and biophysical approaches. In particular, we develop fluorescence imaging approaches to visualise their dynamics at the single-molecule level. Our work also draws on approaches from the physical sciences including surface chemistry, microfluidics and automated image analysis.

More information on our current projects and news are available on our group website.

Group Members

Dr Till Böcking Group Leader, ARC Future Fellow
Dr Thomas SobeyVice-Chancellor's Postdoctoral Fellow
Mr Walid Al-Zyoud Postgraduate student
Ms Quill BowdenPostgraduate student
Mr Peyman ObeidyPostgraduate student (Joint supervisor: Prof Gunning)
Ms Siti Hawa NgalimPostgraduate student (Joint supervisor: A/Prof Gaus)

Key Publications

Böcking T; Aguet F; Harrison SC; Kirchhausen T. Single molecule analysis of a molecular disassemblase: Mechanism of Hsc70-driven clathrin uncoating, Nature Structural & Molecular Biology, 2011, 18 (3) 295-301 (cover article).

Xing Y; Böcking T; Wolf M; Kirchhausen T; Harrison SC. The structure of a clathrin coat with specifically bound Hsc70 and auxilin suggests a mechanism for Hsc70-facilitated disassembly, EMBO Journal, 2010, 29 (3), 655-665.

Böcking T; Kilian KA; Reece P; Gaus K; Gal M; Gooding JJ. Substrate independent assembly of optical structures guided by biomolecular interactions, ACS Applied Materials and Interfaces, 2010, 2 (11) 3270-3275.

Böcking T; Kilian KA; Gaus K; Gooding JJ. Modifying porous silicon with self-assembled monolayers for biomedical applications: the influence of surface coverage on stability and biomolecule coupling. Advanced Functional Materials, 2008, 18, 3827-3833.

(+) Kilian KA; (+) Böcking T; Gaus K; Gooding JJ. Introducing distinctly different chemical functionalities onto the internal and external surfaces of mesoporous materials. Angewandte Chemie, International Edition, 2008, 47, 2697-2699.

(+) equal contribution (+) Salomon A; (+) Böcking T; Gooding JJ; Cahen D. How Important Is the Interfacial Chemical Bond for Electron Transport through Alkyl Chain Monolayers? Nano Letters, 2006, 6, 2873-2876. (+) equal contribution


Funding Sources

Centre for Vascular Research - UNSW - Faculty of Medicine NSW 2052 Australia | Tel: +61 (2) 9385 2536 Fax: +61 (2) 9385 1797
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